Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase, which converts...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perioperative Considerations in Patients With Rett Syndrome as Compared With Those With Cerebral Palsy.

Spine·2024
Same author

Probing a neural unreliability account of auditory sensory processing atypicalities in Rett Syndrome.

Journal of neurodevelopmental disorders·2024
Same author

Probing a neural unreliability account of auditory sensory processing atypicalities in Rett Syndrome.

Research square·2024
Same author

Probing a neural unreliability account of auditory sensory processing atypicalities in Rett Syndrome.

medRxiv : the preprint server for health sciences·2024
Same author

Ambulatory Neuromuscular Scoliosis Patients Have Superior Perioperative Results Than Nonambulatory Neuromuscular Scoliosis Patients and Can Approach Adolescent Idiopathic Scoliosis Outcomes After Posterior Spinal Fusion.

Spine·2021
Same author

Measures of attention in Rett syndrome: Internal consistency reliability.

Neuropsychology·2021

Related Experiment Video

Updated: Jul 10, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
06:21

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform

Published on: May 10, 2024

Folate-responsive neurologic diseases.

Aleksandra Djukic1

  • 1Department of Neurology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA. adjukic@montefiore.org

Pediatric Neurology
|November 21, 2007
PubMed
Summary

Folate is essential for human health, playing vital roles in DNA repair and neurotransmitter synthesis. Early diagnosis of folate deficiency is crucial, especially in pediatric neurological disorders, as treatment with folinic acid can prevent severe outcomes.

More Related Videos

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes
03:19

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes

Published on: June 28, 2024

Related Experiment Videos

Last Updated: Jul 10, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
06:21

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform

Published on: May 10, 2024

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes
03:19

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes

Published on: June 28, 2024

Area of Science:

  • Biochemistry
  • Human Physiology
  • Nutritional Science

Background:

  • Folate, a B-complex vitamin, is vital for human health, growth, and development, but cannot be synthesized internally.
  • It acts as a cofactor in critical physiological processes, including genome maintenance, gene expression regulation, amino acid metabolism, neurotransmitter synthesis, and myelin formation.
  • Dietary folates require complex absorption and metabolic pathways for cellular utilization.

Purpose of the Study:

  • To highlight the diverse clinical conditions associated with abnormal folate status.
  • To emphasize the importance of recognizing central nervous system folate deficiency, even with normal systemic levels.
  • To underscore the critical need for early diagnosis and intervention in unexplained pediatric neurological disorders.

Main Methods:

  • Review of clinical conditions linked to folate status.
  • Analysis of folate's role in neurological development and function.
  • Evaluation of treatment responses to folinic acid in neurological disorders.

Main Results:

  • Abnormal folate status can lead to a spectrum of conditions, from genetic syndromes to embryogenesis malformations (e.g., neural tube defects) and acquired progressive disorders.
  • Central nervous system folate deficiency can manifest independently of systemic folate levels.
  • A majority of patients with neurological issues related to folate deficiency respond favorably to folinic acid treatment.

Conclusions:

  • Pediatric neurologists must maintain a high index of suspicion for folate deficiency in patients with unexplained neurological disorders.
  • Early diagnosis and treatment with folinic acid are essential to prevent severe and potentially irreversible neurological damage.
  • Folate's critical role in neurological health necessitates ongoing vigilance for deficiency states.