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Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
Published on: March 3, 2021
Is hypothermia useful in malignant ischemic stroke? Current status and future perspectives
Arturo Jaramillo1, Sergio Illanes, Violeta Díaz
1Stroke Unit, Hospital Clínico Universidad de Chile, Santiago, Chile. ajaramillo@redclinicauchile.cl
Journal of the Neurological Sciences
|November 21, 2007
Summary
Mild hypothermia (MH) shows mild benefits for acute ischemic stroke patients, improving mortality and outcomes. Further randomized clinical trials are needed to confirm the effectiveness and safety of this treatment.
Area of Science:
- Neurology
- Critical Care Medicine
- Therapeutic Hypothermia
Background:
- Mild and moderate hypothermia (MH) is being investigated for acute stroke patients.
- MH shows potential for controlling intracranial pressure (ICP) in malignant ischemic stroke.
- Controversy persists regarding the effectiveness and safety of MH in stroke treatment.
Purpose of the Study:
- To review recent clinical trial results of MH in acute stroke.
- To analyze potential future applications of MH for stroke patients.
- To evaluate the feasibility and efficacy of MH in managing ischemic stroke.
Main Methods:
- Systematic search of MEDLINE/PubMed and Cochrane Library.
- Inclusion of studies on severe, massive, malignant, or hemispheric ischemic stroke.
- Consideration of animal studies with focal cerebral or brain ischemic models.
Main Results:
- 196 patients with ischemic stroke treated with hypothermia were reported across eleven small clinical studies.
- A mild benefit of MH was observed regarding mortality rates and final patient outcomes.
- Hypothermia ameliorates ischemic injury through multiple mechanisms.
Conclusions:
- Moderate hypothermia is a feasible treatment for acute ischemic stroke patients.
- MH demonstrates potential in improving outcomes and reducing mortality.
- Further randomized clinical trials are warranted to establish definitive efficacy and safety.
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