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Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

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Published on: August 12, 2019

Brain anatomy differences in childhood stuttering.

Soo-Eun Chang¹, Kirk I Erickson, Nicoline G Ambrose

¹Laryngeal and Speech Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. changsoo@ninds.nih.gov

|November 21, 2007

Summary

This summary is machine-generated.

Children at risk for stuttering show reduced gray matter volume in speech areas. Persistent stuttering in children is linked to reduced white matter integrity in the left hemisphere speech system.

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Area of Science:

Neuroscience
Developmental Pediatrics
Speech-Language Pathology

Background:

Stuttering is a common developmental speech disorder with high spontaneous remission rates.
Previous adult studies indicated left white matter deficits and reversed asymmetries in persistent stuttering.
Childhood stuttering may involve distinct neurodevelopmental differences compared to adults.

Purpose of the Study:

To investigate brain structure and white matter integrity in children at risk for stuttering.
To compare neuroimaging findings in children with persistent stuttering, recovered stuttering, and fluent peers.
To identify early biomarkers associated with stuttering development and persistence.

Main Methods:

Optimized voxel-based morphometry (VBM) for gray matter volume (GMV) analysis.
Diffusion tensor imaging (DTI) to measure fractional anisotropy (FA) in white matter tracts.
Comparison of three groups: persistent stuttering, recovered stuttering, and fluent children.

Main Results:

Reduced GMV in speech-relevant regions (left inferior frontal gyrus, bilateral temporal) in both persistent and recovered stuttering groups.
Reduced FA in left white matter tracts underlying motor speech regions in the persistent stuttering group.
No right hemisphere structural increases or reversed asymmetries observed, unlike in adult studies.

Conclusions:

Childhood stuttering risk is associated with gray matter volume deficiencies in the left hemisphere.
Persistent stuttering in children is linked to reduced white matter integrity within the left hemisphere speech system.
Observed differences in children suggest neuroplasticity plays a crucial role in the developmental trajectory of stuttering.