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Related Concept Videos

Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
Inflammation01:38

Inflammation

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Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

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Related Experiment Video

Updated: Jul 10, 2026

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
06:28

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

Inflammation and exercise (INFLAME): study rationale, design, and methods.

Angela M Thompson1, Catherine R Mikus, Ruben Q Rodarte

  • 1Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.

Contemporary Clinical Trials
|November 21, 2007
PubMed
Summary
This summary is machine-generated.

This study investigated exercise training effects on C-Reactive Protein (CRP) in sedentary adults. Moderate-to-vigorous exercise may reduce CRP, influencing coronary heart disease risk assessment.

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A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
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Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
07:26

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Published on: October 17, 2018

Area of Science:

  • Exercise physiology
  • Cardiovascular health
  • Inflammation markers

Background:

  • High-sensitivity C-Reactive Protein (CRP) is a marker for cardiovascular disease risk.
  • Sedentary lifestyles are associated with elevated CRP levels.
  • Understanding exercise's impact on CRP is crucial for preventative health strategies.

Purpose of the Study:

  • To determine the effect of exercise training on elevated CRP concentrations in sedentary adults.
  • To assess exercise's influence on secondary markers of inflammation and cardiovascular health.
  • To investigate potential biological mechanisms linking exercise to CRP reduction.

Main Methods:

  • The INFLAME study randomized 170 healthy, sedentary adults with elevated CRP (>or=2.0 mg/L) into exercise and control groups.
  • The exercise group underwent four months of supervised aerobic training at 60-80% VO(2) max, targeting 16 kcal/kg/week.
  • Primary outcome: change in plasma CRP concentration; secondary outcomes: visceral adiposity, IL-6, TNF-alpha, and heart rate variability (HRV).

Main Results:

  • The primary outcome measured was the change in plasma CRP concentration.
  • Secondary outcomes included changes in visceral adiposity, IL-6, TNF-alpha, and HRV.
  • Analysis aimed to elucidate mechanisms by which exercise influences CRP.

Conclusions:

  • Moderate-to-vigorous exercise training can impact CRP concentrations in sedentary individuals.
  • This study is the largest to date examining exercise effects specifically on CRP.
  • Findings may inform therapeutic applications for coronary heart disease risk assessment and contribute to exercise science literature.