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[Effects of 5F from Pteris semipinnate L on growth of human pathological scars in nude mice]
Yun-song Zhang1, Jing-hua He, Shao-jun Luo
1Department of Plastic Surgery, Guangzhou Red Cross Hospital, Southern Medical University, Guangzhou 510220, China. yszhang5201314@163.com
Objective:
To investigate the effect of 5F from Pteris semipinnate L on the growth of human pathological scar in nude mice.
Methods:
5F from Pteris semipinnate L was administered at different doses in nude mouse models bearing human pathological scars. The morphology, histology, tumor growth factor-beta1 and type I collagen content of the scar tissues were examined after the administration.
Results:
Administration of 5F significantly reduced the volume of the implanted pathological scars in the nude mouse models, and histologically, the scar tissue exhibited a transition to the normal scar architecture with decreased TGF-beta1 and type I collagen content.
Conclusion:
5F could effectively inhibit the growth of pathological scars in nude mice.
