Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[MD-NET--muscular dystrophy network].

H Lochmüller1, V Straub

  • 1Ludwig-Maximilians-Universität, München, BRD. hanns.lochmueller@ncl.ac.uk

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
|November 21, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In response to Gulcin Akinci's and Haluk Topaloglu's letter regarding our article "Predictors of loss of ambulation in Duchenne muscular dystrophy: A systematic review and meta-analysis".

Journal of neuromuscular diseases·2025
Same author

Predictors of Loss of Ambulation in Duchenne Muscular Dystrophy: A Systematic Review and Meta-Analysis.

Journal of neuromuscular diseases·2024
Same author

Axial involvement as a prominent feature in SMPX-related distal myopathy.

Neuromuscular disorders : NMD·2024
Same author

Factors Associated with Respiratory Health and Function in Duchenne Muscular Dystrophy: A Systematic Review and Evidence Grading.

Journal of neuromuscular diseases·2023
Same author

Patient reported pregnancy and birth outcomes in genetic neuromuscular diseases.

Neuromuscular disorders : NMD·2023
Same author

The impact of testosterone therapy on quality of life in adolescents with Duchenne muscular dystrophy.

Neuromuscular disorders : NMD·2021
Same journal

[The progress of participation research. A sociological analysis of its institutionalization].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2026
Same journal

[Applying the German demand planning guideline to maternity care provision: regional and socioeconomic disparities].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2026
Same journal

[Medical aids for children and adolescents following the legislative change-a status report].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2026
Same journal

[Doping: caught between fraud, health protection, and responsibility].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2026
Same journal

[Aging with intellectual and developmental disabilities or severe multiple disabilities-health, participation, and care in later life].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2026
Same journal

[Sexual self-determination and disability: 10 years of the ReWiKs project-dynamics and findings].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2026
See all related articles

Muscular dystrophies (MD) are inherited muscle-weakening disorders affecting thousands in Germany. Current treatments manage symptoms, but a cure remains elusive, highlighting the need for further research.

Area of Science:

  • Neurology
  • Genetics
  • Cell Biology

Context:

  • Muscular dystrophies (MD) are rare inherited disorders affecting skeletal and cardiac muscle.
  • Affecting 1:2000 to 1:3000 individuals in Germany, MD impacts a significant population.
  • Over 30 distinct forms of MD exist, each with unique genetic defects.

Purpose:

  • To summarize the current understanding of muscular dystrophies.
  • To highlight the challenges in diagnosing and treating MD.
  • To emphasize the need for continued research and network initiatives like MD-NET.

Summary:

  • MD are characterized by progressive muscle fiber destruction and replacement by fatty/fibrous tissue.
  • Defects in sarcolemma, nuclear, sarcomeric, or cytoplasmic proteins cause various MD forms.

Related Experiment Videos

  • The precise pathogenic mechanisms leading to muscle decay are not fully understood.

    • Impact:

    • MD currently have no cure, with treatments focusing on symptom management and delaying progression.
    • Physiotherapy, surgery, and medication are key treatment modalities.
    • Symptomatic therapies, such as pacemakers, can be life-saving and improve patient quality of life.