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Updated: Jul 10, 2026
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Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
Published on: April 16, 2012
CD4+CD25+Foxp3+ regulatory T cells: from basic research to potential therapeutic use
Christian Mottet1, Dela Golshayan
1Division of Gastroenterology & Hepatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. christian.mottet@chuv.ch
Swiss Medical Weekly
|November 21, 2007
Summary
Regulatory T cells, or TREG cells, are crucial for balancing immunity and tolerance. This review covers their characteristics, actions, and therapeutic potential in diseases caused by immune system imbalance.
Area of Science:
- Immunology
- Cell Biology
Background:
- Regulatory T cells (TREG) are essential for maintaining immune homeostasis.
- They balance immune responses to self- and foreign-antigens, preventing autoimmunity while allowing effective immunity.
Purpose of the Study:
- To review recent advancements in the understanding of CD4+CD25+Foxp3+ regulatory T cells.
- To detail their characteristics, functions, and mechanisms of action.
Main Methods:
- Literature review of recent key developments in TREG cell research.
- Analysis of disease models involving TREG cell imbalance.
Main Results:
- TREG cells exhibit diverse activities and mechanisms crucial for immune regulation.
- Imbalances between TREG cells and effector T cells are implicated in various diseases.
Conclusions:
- Understanding TREG cell dynamics is key to addressing immune-related disorders.
- TREG cells hold significant potential for novel therapeutic strategies in human diseases.
