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Related Experiment Video

Updated: Jul 10, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

Chemical biology that controls DNA structure and function.

Hiroshi Sugiyama¹

¹Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo, Kyoto 606-8502, Japan. hs@kuchem.kyoto-u.ac.jp

Nucleic Acids Symposium Series (2004)

|November 22, 2007

Summary

Scientists are exploring chemical biology to control DNA structure and function for gene expression regulation. This approach offers potential for knowledge-based therapies targeting diseases like cancer.

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Area of Science:

Biochemistry
Molecular Biology
Chemical Biology

Background:

Genetic information is encoded in DNA's 3 billion base pairs.
DNA conformation influences gene expression.
Understanding DNA sequence and structure is key for disease insights.

Purpose of the Study:

To present long-term efforts in controlling DNA structure and function.
To explore chemical biological approaches for gene expression regulation.

Main Methods:

Chemical biology strategies.
Investigating DNA structure-function relationships.

Main Results:

Demonstrated control over DNA structure.
Influenced DNA function through chemical biological means.

Conclusions:

Chemical biology offers a promising avenue for knowledge-based therapies.
Direct control of gene expression is achievable through DNA manipulation.