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Related Experiment Videos

Proton pump inhibitor utilization patterns in infants.

John J Barron1, Hiangkiat Tan, James Spalding

  • 1HealthCore, Inc, Wilmington, DE, USA. jbarron@healthcore.com

Journal of Pediatric Gastroenterology and Nutrition
|November 22, 2007
PubMed
Summary
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Proton pump inhibitor (PPI) use in infants and neonates increased fourfold between 2000 and 2003. These findings highlight current PPI dosing patterns for pediatric gastroesophageal reflux disease, informing future clinical trials.

Area of Science:

  • Pediatric Gastroenterology
  • Neonatal Pharmacology
  • Drug Utilization Studies

Background:

  • Pediatric gastroesophageal reflux disease (GERD) management often involves acid suppression.
  • Proton pump inhibitors (PPIs) are frequently used in infants, but utilization patterns require examination.

Purpose of the Study:

  • To investigate the utilization patterns of proton pump inhibitors (PPIs) in infants and neonates.
  • To assess demographic information and PPI dosing in a pediatric population.

Main Methods:

  • Retrospective observational study using data from 1999-2004 across four US healthcare plans.
  • Identified infants (<12 months) with at least one PPI pharmacy claim.
  • Assessed demographic data, PPI utilization, and dosing via chart review in a subset.

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Main Results:

  • PPI use increased fourfold from 2000-2003, with lansoprazole and omeprazole being predominant.
  • Commonly associated diagnoses included gastroesophageal reflux, feeding problems, and upper respiratory infections.
  • Longer PPI duration correlated with increased comorbidities; median daily dosages were established for lansoprazole and omeprazole.

Conclusions:

  • PPI utilization in infants and neonates showed a steady increase from 1999 to 2004.
  • The study provides crucial data on PPI dosing patterns in infants.
  • Findings can inform the design of future clinical trials for pediatric GERD.