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Updated: Jul 9, 2026

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
Published on: August 20, 2007
[Interleukin-1 receptor antagonist-treatment of patients with type 2 diabetes]
Claus Morten Larsen1, Mirjam Faulenbach, Allan Vaag
1Steno Diabetes Center, Universitets Hospitalet, Zürich, Universitet i Lund, og Karolinska Institutet, Stockholm. cmla@steno.dk
Abstract:
Interleukin-1 receptor antagonist (IL-1Ra) expression is reduced in islets of patients with type 2 diabetes. 70 patients with type 2 diabetes were randomized to treatment with anakinra (IL-1Ra) or placebo for 13 weeks. Following treatment glycated hemoglobin was 0.46 percent lower, C-peptide secretion was enhanced, and systemic IL-6 and C-reactive protein levels were reduced in the anakinra group compared to the placebo group. Insulin resistance remained unchanged. Blocking IL-1 activity improved glycemia and b-cell secretory function and reduced markers of systemic inflammation.
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