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[Aspergillosis and sarcoidosis]
S Lachkar1, S Dominique, L Thiberville
1Service de Pneumologie, CHU Charles Nicolle, Rouen, France.
Revue Des Maladies Respiratoires
|November 23, 2007
Summary
Diffuse fibrosing sarcoidosis increases the risk of aspergillosis, a serious fungal infection. Early detection and treatment are crucial due to the poor prognosis associated with this complication.
Area of Science:
- Pulmonology
- Infectious Diseases
- Mycology
Background:
- Diffuse fibrosing sarcoidosis is a significant risk factor for Aspergillus sp. infection.
- Patients with chronic fibrosing sarcoidosis, particularly with cystic changes or cavitation in upper lobes, are most susceptible to aspergillosis.
Observation:
- Aspergilloma is the most common form, often challenging to differentiate from chronic necrotizing aspergillosis.
- Sarcoidosis-associated aspergillosis is linked to a higher incidence of respiratory failure and fatal hemoptysis.
Findings:
- Oral antifungal drugs and bronchial embolization show limited efficacy in treating sarcoidosis with aspergillosis.
- Surgical intervention is frequently required but complicated by extensive lesions and compromised respiratory function.
Implications:
- Newer antifungal agents like voriconazole and posaconazole may offer improved treatment outcomes.
- Prompt diagnosis and management of aspergillosis in sarcoidosis patients are essential for improving prognosis.
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