[Frequency and character of side effects of anti-tubercular drugs]

The adverse drug effects (ADE) was found in 66.2% of patients during antituberculosis chemotherapy. The development of structural changes induced by antituberculous drugs was evidenced by histological examination of the biopsy specimens of the gastric mucosa, duodenum and liver. It is concluded that toxic and allergic components are simultaneously responsible for ADE on the digestive organs. Long-term health studies in subjects who were strucked off the dispensary register in group VII showed that ADE experienced during hospital treatment contributed to the formation of gastroenterologic abnormalities and nonspecific allergization of the body.