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Development of the Heart

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...

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Delayed structural development in an acardiac fetus: an echographic observation.

C Van Gaever¹, P Defoort, M Dhont

¹Department of Obstetrics and Gynaecology, Ghent University Hospital, Ghent, Belgium. cathy_vangaever@hotmail.com

Fetal Diagnosis and Therapy

|November 24, 2007

Summary

Twin reversed arterial perfusion (TRAP) sequence involves abnormal blood flow in identical twins. Despite initial appearance as an amorphic mass, the recipient twin demonstrated significant development, including a spine and limbs.

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Area of Science:

Perinatology
Developmental Biology
Medical Imaging

Background:

Twin reversed arterial perfusion (TRAP) sequence is a rare complication in monochorionic multiple gestations.
It arises from arterio-arterial anastomoses, leading to abnormal placental sharing.
Delayed development in the recipient twin is a characteristic feature.

Observation:

A monochorionic monoamniotic twin pregnancy presented with discordant growth at 11 weeks.
The smaller twin initially appeared as an amorphic mass.
Serial ultrasounds revealed progressive growth and development of fetal structures, including a spine and lower limbs.

Findings:

The case documents the serial ultrasound progression of an acardiac twin.
Remarkable development of recognizable embryonic structures occurred despite initial malformation.
This challenges the notion of a singular point of developmental arrest.

Implications:

Developmental arrest in acardiac fetuses may not be absolute but rather a differential process.
Embryonic fields can continue to develop into macroscopic structures.
This highlights the complex and dynamic nature of twin developmental anomalies.