Related Experiment Video
Updated: Jul 9, 2026

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect
Published on: April 14, 2026
The pathomechanism of degenerative changes in joints
1Katedra i Klinika Ortopedii i Traumatologii Narzadu Ruchu, Akademia Medyczna, Warszawa; Zakład Chirurgii Doświadczalnej i Transplantacyjnej, CMDiK PAN, Warszawa.
Abstract:
Osteoarthritis is a slowly progressive degeneration of articular surfaces, leading to the disruption of the chondral layers of the joint. Modern diagnostic and laboratory techniques make it possible to investigate the mechanism underlying the changes taking place in osteoarthritis and the role of the molecular substances involved in this disease, i.e. matrix metalloproteinases, cytokines and growth factors. The pathomechanism of changes leading to osteochondral disruption of the joint in osteoarthritis are discussed In the present study.
Related Concept Videos
Degenerative Disc Disease ll: Pathophysiology
Degenerative Disc Disease I: Introduction
Structural Joints: Synovial Joints
The Effect of Aging on Tissues
Development of the Limb Synovial Joints
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
Parkinson Disease ll: Pathophysiology