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Related Concept Videos

Microbial Biosensors01:17

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Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
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Related Experiment Video

Updated: Jul 9, 2026

The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions
08:06

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Published on: February 1, 2018

[Biofilters and biosensors].

G S Netti1, D Centonze, L Gesualdo

  • 1Bioagromed, Università degli Studi, Foggia.

Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
|December 6, 2007
PubMed
Summary
This summary is machine-generated.

Sepsis-associated acute renal failure (ARF) has high mortality. Early detection of glucose and lactate via biosensors and bioartificial kidneys combining hemofiltration with cell therapy can improve patient outcomes.

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Area of Science:

  • Critical care medicine
  • Nephrology
  • Biomedical engineering

Context:

  • Sepsis is a major cause of death in ICUs, often leading to acute renal failure (ARF).
  • Hyperglycemia and elevated lactate are poor prognostic markers in sepsis, preceding organ dysfunction.
  • Current ARF treatments using synthetic membranes lack crucial kidney functions.

Purpose:

  • To explore advanced monitoring and therapeutic strategies for sepsis-induced ARF.
  • To highlight the potential of biosensors for early detection of critical parameters.
  • To investigate the role of bioartificial kidneys in restoring renal function.

Summary:

  • Direct online measurement using amperometric biosensors can detect glucose and lactate levels early.
  • Cell therapy integrated with hemofiltration in a bioartificial kidney can replace lost renal functions.
  • This approach has shown promise in animal models and early clinical trials for ARF.

Impact:

  • Improved prognosis for septic patients with ARF through integrated monitoring and treatment.
  • Potential to restore filtration, transport, metabolic, and endocrine functions lost in ARF.
  • Emphasizes the need for multidisciplinary collaboration to develop novel devices for managing sepsis complications.