Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

MicroRNAs in synapse development: tiny molecules to remember.

Roberto Fiore1, Gerhard Schratt

  • 1University of Heidelberg, Interdisciplinary Centre for Neurosciences (IZN), SFB488 Junior Group, and University Hospital of Heidelberg, Institute for Anatomy and Cell Biology, Department of Neuroanatomy, Im Neuenheimer Feld 345, 69120 Heidelberg, Germany.

Expert Opinion on Biological Therapy
|November 24, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcranial pulse stimulation modulates spectral signatures of Alzheimer's disease in the 3×Tg-AD mouse model.

Alzheimer's research & therapy·2026
Same author

Multimodal evaluation of differentiated thyroid cancer patient information booklets: strengths and limitations in content quality, readability, and patient-centered communication.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2026
Same author

The Unexplored Role of Noncoding Regulatory RNAs in Engram Dynamics.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2026
Same author

Cardiovascular Pre-participation Evaluation of Athletes with an Impairment Recruited for Paris 2024 Paralympic Games.

High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension·2025
Same author

Peripheral MicroRNA Expression Patterns as Biomarkers for Adolescent Depression.

Biological psychiatry global open science·2025
Same author

Blood test findings in a large cohort of Olympic athletes: a cross-sectional study.

Journal of science and medicine in sport·2025
Same journal

TNF inhibitors for the long-term management of juvenile idiopathic arthritis associated uveitis: real-life data from the ITHACA cohort.

Expert opinion on biological therapy·2026
Same journal

Type 2 inflammation and biologics: a twenty-year journey.

Expert opinion on biological therapy·2026
Same journal

Current outlook on the use of biological agents to improve outcomes in adult secondary hemophagocytic lymphohistiocytosis.

Expert opinion on biological therapy·2026
Same journal

Addressing challenges in disease management of childhood-onset systemic lupus erythematosus: the role of biologics, with primary focus on rituximab and belimumab.

Expert opinion on biological therapy·2026
Same journal

Biological drugs for the treatment of children with atopic dermatitis.

Expert opinion on biological therapy·2026
Same journal

Optimizing biologic therapy in psoriasis: dose adjustment, treatment duration, and tapering-an expert perspective.

Expert opinion on biological therapy·2026
See all related articles

MicroRNAs regulate genes after transcription and are vital for nervous system development and function. Understanding their role in synapses may lead to new treatments for neurologic diseases.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.
  • miRNAs are crucial for nervous system development, including neuronal patterning and cell specification.
  • Emerging evidence highlights miRNAs' essential role in synaptic development and function.

Purpose of the Study:

  • To review recent findings on microRNA function in synapse formation and plasticity.
  • To explore the potential of targeting the miRNA pathway for treating neurologic diseases.

Main Methods:

  • Literature review of current research on microRNAs in neuroscience.
  • Analysis of studies investigating miRNA involvement in synaptic development and disease.

Related Experiment Videos

Main Results:

  • MicroRNAs are key regulators of synaptic development and plasticity.
  • Dysregulation of miRNAs is implicated in the pathogenesis of synaptic dysfunction-related neurologic disorders.

Conclusions:

  • MicroRNAs are critical for proper synaptic function.
  • The miRNA pathway presents a promising therapeutic target for neurologic diseases.