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Large platelets circulate in an activated state in diabetes mellitus
D Tschoepe1, P Roesen, J Esser
1Diabetes Research Institute, Heinrich Heine University of Duesseldorf, Germany.
Seminars in Thrombosis and Hemostasis
|October 1, 1991
Summary
In diabetes mellitus, platelets show increased activation, particularly larger ones, and are linked to vascular complications. This suggests activated platelets may contribute to the prethrombotic state in diabetic patients.
Area of Science:
- Cardiovascular Research
- Endocrinology
- Hematology
Background:
- Diabetes mellitus is linked to vascular complications.
- The role of platelet hyperreactivity in diabetes pathogenesis is unclear.
Purpose of the Study:
- To investigate platelet activation in diabetes mellitus.
- To assess in vivo platelet activation using CD63 and CD62 markers.
Main Methods:
- Measured CD63 and CD62 expression on platelets in diabetic patients and controls.
- Correlated marker expression with clinical data (angiopathy, blood glucose, HbA1c, platelet count).
Main Results:
- Significantly higher CD63 and CD62-positive platelets in diabetic patients compared to controls.
- Marked increase in activated platelets in patients with angiopathy.
- Increased CD63 fluorescence correlated with larger platelet size in patients.
Conclusions:
- Diabetes mellitus is associated with increased circulating activated platelets, especially larger ones.
- Platelet activation may be linked to vascular lesions in diabetic patients.
- Activated platelets might contribute to the prethrombotic state in diabetes.