Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Desmosomes

Desmosomes

The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein complexes comprising desmosomal...

Papillary Dermis

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

Multipotency and Niche of Bulge Stem Cell

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Tribute to a Master Clinician: Richard Odom.

JAMA dermatology·2026

Same author

Disability-related care trajectories in a pluralistic health system: a qualitative study in urban Sierra Leone.

BMC public health·2026

Same author

Independent Head-to-Head Comparison of Commercial Artificial Intelligence Devices for Lung Cancer Detection on Chest Radiographs.

Radiology·2026

Same author

CARMN fusions and PDGFRB mutations highlight key differences among cutaneous tumors with myopericytic differentiation.

The Journal of investigative dermatology·2026

Same author

Novel fusion gene THBS1::ERBB2 drives a subset of superficial acral fibromyxomas.

The British journal of dermatology·2026

Same author

A Safe and Effective Internal Medicine Procedure Rotation for Medical Students.

Medical science educator·2026

Search research articles

Related Experiment Video

Updated: Jul 9, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Medallion-like dermal dendrocyte hamartoma.

Kara N Shah¹, Elizabeth Anderson, Jacqueline Junkins-Hopkins

¹Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Pediatric Dermatology

|November 27, 2007

Summary

Medallion-like dermal dendrocyte hamartomas are rare congenital skin lesions. These benign growths feature a unique CD34-positive spindle cell proliferation in the dermis.

More Related Videos

Morphological Analysis of Drosophila Larval Peripheral Sensory Neuron Dendrites and Axons Using Genetic Mosaics

Morphological Analysis of Drosophila Larval Peripheral Sensory Neuron Dendrites and Axons Using Genetic Mosaics

Published on: November 7, 2011

Isolating Primary Melanocyte-like Cells from the Mouse Heart

Isolating Primary Melanocyte-like Cells from the Mouse Heart

Published on: September 29, 2014

Related Experiment Videos

Last Updated: Jul 9, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Morphological Analysis of Drosophila Larval Peripheral Sensory Neuron Dendrites and Axons Using Genetic Mosaics

Morphological Analysis of Drosophila Larval Peripheral Sensory Neuron Dendrites and Axons Using Genetic Mosaics

Published on: November 7, 2011

Isolating Primary Melanocyte-like Cells from the Mouse Heart

Isolating Primary Melanocyte-like Cells from the Mouse Heart

Published on: September 29, 2014

Area of Science:

Dermatology
Pathology
Immunology

Background:

Medallion-like dermal dendrocyte hamartomas (MDDH) are exceptionally rare congenital cutaneous lesions.
Only three cases have been previously documented in English literature, highlighting their rarity.

Observation:

MDDH typically manifest at birth as asymptomatic, well-defined atrophic patches.
These lesions present with a characteristic pliable, wrinkled surface, often with an erythematous or yellow-brown hue and subtle telangiectases.
They can be mistaken for other skin conditions like atrophoderma or anetoderma.

Findings:

Histological examination reveals epidermal atrophy and a distinctive proliferation of CD34-positive spindle cells within the dermis.
This proliferation consists of dermal dendrocytes, which are bone marrow-derived cells integral to the skin's immune system.
The pathophysiology of MDDH remains largely unelucidated.

Implications:

This case contributes to the limited understanding of MDDH, a rare skin condition.
Accurate diagnosis is crucial to differentiate MDDH from other cutaneous disorders.
Further research into the pathophysiology of MDDH may offer insights into dermal dendrocyte function and skin immunity.