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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

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Pemphigus and HLA in Morocco.

C Brick¹, F Z Belgnaoui, O Atouf

¹Service de transfusion sanguine et d'hémovigilance, unité d'immunologie, hopîtal Ibn Sina, 10000 Rabat, Morocco. brickchehrazade@yahoo.fr

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine

|November 27, 2007

Summary

This study found specific Human Leukocyte Antigen (HLA) genes are associated with pemphigus susceptibility and protection in Morocco. These findings confirm a genetic predisposition to pemphigus in the Moroccan population.

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Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

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Published on: October 15, 2021

Area of Science:

Immunogenetics
Dermatology
Autoimmune Diseases

Background:

Pemphigus is an autoimmune blistering disease targeting keratinocyte adhesion molecules.
Human Leukocyte Antigen (HLA) class II genes, especially DR4 and DR14, show known associations with pemphigus globally.
Genetic predisposition to pemphigus has been observed across various ethnic groups.

Purpose of the Study:

To investigate the association between pemphigus subtypes and HLA genes in the Moroccan population for the first time.
To identify specific HLA alleles and haplotypes linked to pemphigus susceptibility or protection in Morocco.

Main Methods:

Compared 52 unrelated Moroccan pemphigus patients with 178 healthy controls.
Utilized complement-dependent microlymphocytotoxic method for HLA class I typing.
Employed sequence-specific primer amplification for HLA class II typing.

Main Results:

No significant association found with HLA-A or HLA-B antigens.
Increased frequencies of DRB1*04, DRB1*14, and DQB1*03 alleles observed.
Decreased frequencies of DRB1*15 and DQB1*06 alleles noted, suggesting a protective effect for the DRB1*15-DQB1*06 haplotype.
DRB1*04-DQB1*03 and DRB1*14-DQB1*05 haplotypes linked to increased susceptibility.

Conclusions:

Results confirm a genetic predisposition to pemphigus in the Moroccan population.
Identified specific HLA alleles and haplotypes influencing pemphigus risk.
The observed susceptibility alleles are similar to those found globally, suggesting genetic factors alone do not fully explain pemphigus prevalence in Morocco.