Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Commentary: behavioral phenotype.

Melly S Oitzl1

  • 1Division of Medical Pharmacology, LACDR/LUMC, University of Leiden, 2300 RA, Leiden, The Netherlands. m.oitzl@lacdr.leidenuniv.nl

Progress in Brain Research
|November 27, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stress Induces a Shift Towards Striatum-Dependent Stimulus-Response Learning via the Mineralocorticoid Receptor.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2016
Same author

Blocking glucocorticoid receptors at adolescent age prevents enhanced freezing between repeated cue-exposures after conditioned fear in adult mice raised under chronic early life stress.

Neurobiology of learning and memory·2016
Same author

Overexpression of mineralocorticoid receptors does not affect memory and anxiety-like behavior in female mice.

Frontiers in behavioral neuroscience·2015
Same author

A Stress-Induced Shift From Trace to Delay Conditioning Depends on the Mineralocorticoid Receptor.

Biological psychiatry·2015
Same author

Immediate Effects of Maternal Deprivation on the (Re)Activity of the HPA-Axis Differ in CD1 and C57Bl/6J Mouse Pups.

Frontiers in endocrinology·2014
Same author

Blocking the mineralocorticoid receptor in humans prevents the stress-induced enhancement of centromedial amygdala connectivity with the dorsal striatum.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2014
Same journal

Preface.

Progress in brain research·2025
Same journal

Mindfulness and meditation: Promoting emotional and cognitive health.

Progress in brain research·2025
Same journal

Cognitive stimulation enhancing memory and mental function.

Progress in brain research·2025
Same journal

The science behind non-pharmacological interventions.

Progress in brain research·2025
Same journal

Technology-assisted interventions for neuropsychiatric disorders.

Progress in brain research·2025
Same journal

Ethical consideration in non-pharmacological treatments for neuropsychiatric disorders.

Progress in brain research·2025
See all related articles

Post-traumatic stress disorder (PTSD) results from severe stress. Animal models explore traumatic memory, extinction, and stress system activity in PTSD vulnerability.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Behavioral Science

Background:

  • Post-traumatic stress disorder (PTSD) is intrinsically linked to acute, severe stressors.
  • Understanding the neurobiological underpinnings of PTSD is crucial for developing effective treatments.

Purpose of the Study:

  • To outline the core components of animal models used in PTSD research.
  • To highlight the significance of traumatic memory formation, extinction, and stress system activity in PTSD.

Main Methods:

  • Review of existing literature on animal models for PTSD.
  • Focus on the role of memory processes and neuroendocrine stress responses.

Main Results:

  • Animal models effectively simulate key aspects of PTSD pathophysiology.

Related Experiment Videos

  • These models facilitate the study of traumatic memory consolidation and extinction processes.
  • They also allow for the investigation of sympathetic and adrenocortical system activity.

    • Conclusions:

    • Animal models are essential tools for dissecting the complex mechanisms of PTSD.
    • Research in these models focuses on memory, extinction, and stress system interactions.
    • Individual vulnerability factors are integral to understanding PTSD development.