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Takayasu arteritis: what is the long-term prognosis?
Kathleen Maksimowicz-McKinnon1, Gary S Hoffman
1Division of Rheumatology and Clinical Immunology, University of Pittsburgh, 3500 Terrace Street, BST S718, Pittsburgh, PA 15261, USA. mckinnonk@dom.pitt.edu
Rheumatic Diseases Clinics of North America
|November 27, 2007
Summary
Takayasu arteritis (TA), a large vessel vasculitis, is not self-limiting and often leads to chronic glucocorticoid dependence and disability. Tumor necrosis factor (TNF) inhibition shows promise as a potential therapy.
Area of Science:
- Rheumatology
- Immunology
- Vascular Medicine
Background:
- Takayasu arteritis (TA) is an idiopathic large vessel vasculitis primarily affecting women of reproductive age.
- Historically perceived as benign, contemporary data reveal a more complex and often severe disease course.
Purpose of the Study:
- To provide updated insights into the clinical course and outcomes of Takayasu arteritis.
- To evaluate the potential of targeted therapies, such as tumor necrosis factor (TNF) inhibition.
Main Methods:
- Analysis of longitudinal data from multiple countries.
- Review of contemporary studies on TA clinical presentation and progression.
Main Results:
- Takayasu arteritis is recognized as a relapsing condition.
- Patients frequently experience chronic dependence on glucocorticoids and resultant disability.
- Preliminary data suggest efficacy of TNF inhibition in TA treatment.
Conclusions:
- Takayasu arteritis is a chronic, potentially disabling disease requiring long-term management.
- Targeted therapies like TNF inhibitors warrant further investigation for TA treatment.
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