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Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
Published on: May 19, 2023
TNF-alpha and adipocyte biology.
William P Cawthorn1, Jaswinder K Sethi
1Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
FEBS Letters
|November 27, 2007
Summary
Tumor necrosis factor-alpha (TNF-alpha) disrupts adipose tissue function, contributing to metabolic disorders like obesity and diabetes. This review details how TNF-alpha impairs fat tissue
Area of Science:
- Metabolic research
- Adipose tissue biology
- Inflammation and metabolism
Background:
- Dyslipidemia and insulin resistance are linked to catabolic and obesity-related conditions.
- Adipose tissue dysfunction and elevated tumor necrosis factor-alpha (TNF-alpha) are common features.
- TNF-alpha is a pro-inflammatory adipokine with significant metabolic impact.
Purpose of the Study:
- To review the diverse actions of TNF-alpha on adipose tissue.
- To elucidate TNF-alpha's role in metabolic dysregulation.
- To discuss the molecular mechanisms underlying TNF-alpha's effects.
Main Methods:
- Literature review of TNF-alpha's functions in adipose tissue.
- Analysis of TNF-alpha's impact on key metabolic pathways.
- Examination of TNF-alpha's influence on adipose tissue endocrine functions.
Main Results:
- TNF-alpha inhibits carbohydrate metabolism, lipogenesis, adipogenesis, and thermogenesis.
- TNF-alpha stimulates lipolysis in adipose tissue.
- Impaired adipose tissue function and fuel storage contribute to metabolic dysregulation.
Conclusions:
- TNF-alpha significantly contributes to metabolic disorders by disrupting adipose tissue homeostasis.
- Understanding TNF-alpha's mechanisms is crucial for addressing dyslipidemia and insulin resistance.
- Targeting TNF-alpha may offer therapeutic strategies for metabolic diseases.
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