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Updated: Jul 9, 2026
Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
Published on: June 23, 2023
[CDT: a biological marker of alcohol abuse]
Valeria Crespi1, Ursula Andreotta, Elena Tettamanzi
1Laboratorio di Tossicologia, UO Medicina del Lavoro e Preventiva, Ospedale di Circolo e Fondazione Macchi, Varese. valeria.crespi@ospedale.varese.it
Background:
Laboratory tests may be useful tools in the identification of heavy drinkers, in identifying the etiological role of alcohol in the onset of the disease, and in monitoring changes in alcohol intake.
Objectives:
An ideal diagnostic marker of alcohol abuse should: be characterized by high specificity and sensitivity; show an high specific correlation with alcohol metabolism; be dependent on alcohol intake and have a relatively short half-life (t1/2) so as to be able to monitor abstinence periods.
Conclusions:
CDT (Carbohydrate-Deficient-Transferrin) meets all these requirements and offers the physician a significant tool as a marker of chronic alcohol abuse. CDT can reveal a daily alcohol consumption of 50-80 g of ethanol, corresponding to a bottle of 11 degrees-13 degrees wine, for two consecutive weeks, with normalization after two weeks of abstinence (t1/2 of CDT is 15 days). Compared with other more common alcohol abuse markers, such as GGT or MCK CDT is more specific and provides more detailed information.
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