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Updated: Jul 9, 2026
10:52
Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence
Published on: December 23, 2022
ASD/PFO devices: what is in the pipeline?
Nicolas Majunke1, Horst Sievert
1CardioVascular Center Frankfurt, Frankfurt, Germany.
Journal of Interventional Cardiology
|November 29, 2007
Summary
New transcatheter devices are emerging for closing atrial septal defects (ASD) and patent foramen ovale (PFO). This review examines devices not yet approved in the US, alongside experimental options for intracardiac shunts.
Area of Science:
- Cardiovascular Medicine
- Medical Devices
- Interventional Cardiology
Background:
- Atrial septal defects (ASD) and patent foramen ovale (PFO) are congenital heart conditions requiring closure.
- Transcatheter device development for intracardiac shunts has evolved significantly since the 1970s.
- Minimizing foreign material in the atria is a key trend in device design.
Purpose of the Study:
- To review novel transcatheter devices for ASD and PFO closure.
- To highlight devices approved outside the United States.
- To discuss experimental devices for intracardiac shunt closure.
Main Methods:
- Literature review of transcatheter closure devices for ASD and PFO.
- Focus on devices currently in clinical trials or approved internationally.
- Analysis of experimental device designs and their potential applications.
Main Results:
- A variety of transcatheter devices for ASD and PFO closure are available or in development.
- Several new devices are approved in regions outside the US.
- Experimental devices aim for improved efficacy and reduced foreign body presence.
Conclusions:
- The field of transcatheter intracardiac shunt closure is rapidly advancing with innovative devices.
- International markets offer insights into next-generation ASD and PFO occluders.
- Future research focuses on defect-specific, minimally invasive closure solutions.
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