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The analysis of thiocarbamides by gas chromatography/negative-ion chemical-ionization mass spectrometry
D G Watson1, C D Bates, G G Skellern
1Department of Pharmacy, University of Strathclyde, Glasgow, UK.
Rapid Communications in Mass Spectrometry : RCM
|March 1, 1991
Abstract:
Thiocarbamides were converted to their di-N-pentafluorobenzyl (PFB) derivatives and analysed by gas chromatography/negative-ion chemical-ionization mass spectrometry with methane as reagent gas. The PFB derivatives of the 2-thiouracils gave mass spectra in which the ion current was carried largely by an ion arising from [M-PFB]-. The derivative was used in the determination of the uptake and metabolism of thiocarbamides by cultures of melanoma cells.