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Published on: April 8, 2013
Neural control of human nasal secretion
1National Heart and Lung Institute, London, UK.
Pulmonary Pharmacology
|January 1, 1991
Summary
Sensory nerves and parasympathetic reflexes are key to nasal symptoms like itching and congestion in allergic and non-allergic nasal disorders. Understanding nasal anatomy and provocation studies helps explain these processes.
Area of Science:
- Rhinology
- Neuroscience
- Immunology
Background:
- Allergic and non-allergic nasal disorders share symptoms like itching, discharge, congestion, and airflow obstruction.
- Sensory nerve activity and parasympathetic reflexes are implicated in the pathophysiology of these nasal symptoms.
- Nasal provocation studies offer insights into the mechanisms of nasal secretion and airflow obstruction.
Purpose of the Study:
- To review the anatomy of the nasal mucosa, vasculature, and innervation.
- To discuss the role of sensory nerves and parasympathetic reflexes in nasal disorders.
- To present findings from human nasal provocation studies.
Main Methods:
- Review of anatomical and physiological literature on the nasal mucosa.
- Analysis of results from human nasal provocation studies.
- Discussion of the neuro-anatomical basis of nasal symptoms.
Main Results:
- Detailed review of nasal mucosa anatomy, vasculature, and innervation.
- Explanation of how sensory nerves and parasympathetic reflexes contribute to nasal symptoms.
- Presentation of data from nasal provocation studies on secretions and airflow.
Conclusions:
- Sensory nerves and parasympathetic reflexes are critical in both allergic and non-allergic nasal pathologies.
- Nasal provocation studies provide valuable data on the mechanisms underlying nasal secretions and obstruction.
- A comprehensive understanding of nasal neuro-anatomy is essential for managing nasal disorders.
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