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In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium
Published on: May 6, 2018
Gene therapy in cerebrovascular diseases
Rodney Allanigue Gabriel1, Guo-Yuan Yang
1Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA.
Current Gene Therapy
|November 30, 2007
Summary
Gene therapy shows promise for neurological diseases, including cerebrovascular disorders like cerebral ischemia. This review covers gene delivery methods and future directions for treating brain blood vessel conditions.
Area of Science:
- Neurology
- Genetics
- Vascular Biology
Background:
- Gene therapy is advancing for neuro-oncology and neurodegenerative diseases.
- Cerebrovascular gene therapy remains experimental but shows promise.
- Obstacles must be overcome for successful clinical application.
Purpose of the Study:
- To review gene therapy fundamentals for cerebrovascular diseases.
- To discuss gene delivery vehicles, targeting strategies, and in vivo/ex vivo approaches.
- To explore the future of gene therapy in treating cerebrovascular disorders.
Main Methods:
- Review of viral, non-viral, and cellular gene delivery vehicles.
- Analysis of vector routes and specific delivery to the central nervous system.
- Examination of in vivo and ex vivo gene delivery studies for cerebrovascular injuries.
Main Results:
- Gene therapy approaches have shown success in attenuating cerebrovascular injuries in experimental models.
- Various gene delivery vehicles and targeting strategies are being explored.
- In vivo and ex vivo methods demonstrate potential for therapeutic benefit.
Conclusions:
- Gene therapy holds significant potential for treating cerebrovascular diseases.
- Further research and overcoming delivery challenges are crucial for clinical translation.
- Future advancements in gene therapy could revolutionize the treatment of conditions like cerebral ischemia and arteriovenous malformations.
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