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Isolation of a new antitumor substance from Bacillus stearothermophilus
1Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Chemical & Pharmaceutical Bulletin
|September 1, 1991
Abstract:
A new antitumor substance, BS-1, was isolated from the autolysate and culture filtrate of Bacillus stearothermophilus UK563 by ethylacetate extraction and HPLC. BS-1 inhibited the proliferation of mouse macrophage-like cells, P388-D1 (IC50: 4 micrograms/ml) and mouse mastocytoma, P-815 (IC50: 0.6 microgram/ml), but not that of Balb/c 3T3.