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Correlation between free thyroxin levels and left ventricular ejection fraction in Graves' disease (preliminary
Arif Mansjoer1, Idrus Alwi, Imam Subekti
1Department of Internal Medicine, Faculty of Medicine, University of Indonesia-dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Acta Medica Indonesiana
|November 30, 2007
Summary
Newly diagnosed Graves' disease patients show a strong positive correlation between free thyroxine (fT4) levels and left ventricular ejection fraction (LVEF). Higher fT4 levels are associated with improved cardiac function in these patients.
Area of Science:
- Endocrinology
- Cardiology
- Internal Medicine
Background:
- Graves' disease is an autoimmune disorder leading to hyperthyroidism.
- Thyroid hormones significantly impact cardiovascular function.
- Left ventricular ejection fraction (LVEF) is a key indicator of cardiac systolic function.
Purpose of the Study:
- To investigate the relationship between free thyroxine (fT4) levels and LVEF in patients newly diagnosed with Graves' disease.
- To determine if elevated thyroid hormone levels correlate with changes in left ventricular systolic function.
Main Methods:
- A cross-sectional study design was employed.
- Free thyroxine (fT4) levels were measured in a laboratory setting.
- Left ventricular ejection fraction (LVEF) was assessed using echocardiography (Simpson's method).
Main Results:
- The study included ten newly diagnosed Graves' patients (7 males, 3 females; age 18-52).
- Average fT4 levels were 5.75 ng/dL (SD 0.96).
- Average LVEF was 70.57% (SD 4.50%), with a significant positive correlation (r=0.711, p=0.021) between fT4 and LVEF.
Conclusions:
- A strong positive correlation exists between fT4 and LVEF in newly diagnosed Graves' patients.
- Elevated free thyroxine levels are associated with enhanced left ventricular systolic function in this population.
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