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Updated: Jul 9, 2026

Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure
Published on: October 1, 2019
Dynamic analysis of exercise oxygen consumption predicts outcomes in advanced heart failure
Guy A MacGowan1, Amar Pohwani, Srinivas Murali
1Freeman Hospital, Newcastle upon Tyne, UK. guy.macgowan@nuth.nhs.uk
Abstract:
It is unclear whether cardiopulmonary stress testing provides prognostic information in patients with very advanced heart failure receiving contemporary medical therapy. Analysis of cardiopulmonary treadmill stress data in a group of patients with advanced heart failure and severe functional impairment was performed (N=102, peak exercise oxygen consumption [VO2] < or =14 mL/kg/min, 47% receiving beta-blockers). Dynamic variables (peak - baseline values) better predicted outcomes than did single value peak measurements, especially DeltaVO2. Multivariate analysis showed that usage of beta-blockers and DeltaVO2 (both P<.05) independently and significantly predicted outcomes. Subgroup analysis showed that DeltaVO2 was particularly useful in predicting outcomes in patients with ischemic cardiomyopathy or who were not receiving beta-blockers. Thus, in patients with very advanced heart failure, cardiopulmonary stress testing-derived DeltaVO2 provides important prognostic information useful to help predict clinical deterioration or death, particularly for patients with ischemic cardiomyopathy or who are not receiving beta-blockers.
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