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Processing of Bulk Nanocrystalline Metals at the US Army Research Laboratory

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Published on: March 7, 2018

Anomalous particle size shift during post-milling storage.

Wai Kiong Ng¹, Jin Wang Kwek, Reginald B H Tan

¹Crystallisation and Particle Sciences, Institute of Chemical and Engineering Sciences, Jurong Island, Singapore. ng_wai_kiong@ices.a-star.edu.sg

Pharmaceutical Research

|November 30, 2007

Summary

This summary is machine-generated.

Particle size of milled adipic acid changes during storage due to stress relaxation, not moisture. Proper storage conditions are crucial for maintaining powder stability and particle size distribution.

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Area of Science:

Materials Science
Chemical Engineering
Pharmaceutical Sciences

Background:

Particle size reduction via milling is crucial for many industrial applications.
Post-milling storage can lead to undesirable changes in particle characteristics, impacting product performance.
Understanding particle size shifts during storage is vital for powder stability.

Purpose of the Study:

To investigate the phenomenon of particle size shift in milled adipic acid during post-milling storage.
To elucidate the mechanisms driving these particle size changes under various storage conditions.

Main Methods:

Ball-milled adipic acid was stored under controlled humidity conditions.
Particle size distribution was analyzed using laser diffraction.
Morphology, flow properties, surface adhesion, and crystallinity were characterized using SEM, annular shear tester, AFM, PXRD, and DVS.

Main Results:

Particle size distribution of milled adipic acid varied, showing shifts to finer or coarser fractions depending on storage conditions.
SEM revealed that particle size changes were linked to agglomerate de-aggregation or re-crystallization.
Powder flow improved under high humidity, but electrostatic charges were ruled out as a cause for particle size shifts.

Conclusions:

Particle size reduction occurred via a stress relaxation mechanism, independent of moisture sorption or loss.
Storage below critical relative humidity induced localized disintegration and particle size reduction.
Maintaining appropriate storage conditions is essential for the stability of milled adipic acid powders.