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Is the mineralocorticoid receptor a potential target for stroke prevention?

Jessica M Osmond1, Christine' S Rigsby, Anne M Dorrance

  • 1Department of Physiology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA.

Clinical Science (London, England : 1979)
|December 1, 2007
PubMed

Insights

Mineralocorticoid receptor (MR) antagonism may prevent strokes by protecting cerebral blood vessels. This effect may involve the epidermal growth factor receptor (EGFR) and collagen levels in vessel walls.

Area of Science:

  • Cardiovascular Science
  • Neurology
  • Endocrinology

Background:

  • Aldosterone has significant extra-renal effects contributing to cardiovascular disease pathogenesis.
  • Stroke is a major cause of mortality globally.
  • Mineralocorticoid receptor (MR) antagonism is being investigated as a stroke preventative therapy.

Purpose of the Study:

  • To explore the potential of MR antagonism in preventing both ischaemic and haemorrhagic strokes.
  • To investigate the mechanisms underlying the protective effects of MR antagonism in the cerebral vasculature.

Main Methods:

  • The study focuses on the cerebral vasculature.
  • Investigates the role of epidermal growth factor receptor (EGFR) expression and activation.
  • Examines the impact on vessel wall collagen deposition.

Main Results:

  • MR antagonism demonstrates a protective effect against stroke.
  • This protection is linked to actions within the cerebral vasculature.
  • Potential mechanisms involve EGFR signaling and collagen accumulation.

Conclusions:

  • MR antagonism represents a promising therapeutic strategy for stroke prevention.
  • The protective effects are mediated through the cerebral vasculature.
  • EGFR and collagen deposition are identified as key factors in this protective mechanism.

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