Screening for bone health in epilepsy
Related Experiment Video
Updated: Jul 9, 2026

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
Published on: January 31, 2025
Raj D Sheth1, Cynthia L Harden
1Department of Neurology, University of Wisconsin-Madison, Wisconsin, USA. sheth@neurology.wisc.edu
Abstract:
Elderly and young patients with epilepsy are at risk for fractures from seizure and antiepileptic drug (AED) related falls and from epilepsy and AED related lowered bone mass. Enzyme inducing AEDs are often implicated, although, nonenzyme inducing medications may also impact epilepsy bone disease. Screening for bone health with direct measures, such as bone densitometry by dual-energy x-ray absorptiometry (DEXA) and indirectly via biochemical markers of bone turnover may help identify patients who are at increased risk for fractures and offer an opportunity for intervention.
More Related Videos
Related Concept Videos
Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Seizures: Classification
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

