Related Experiment Video
Updated: Jul 9, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Computer simulation of intracardiac potential with whole-heart model
1Graduate Department of Information Systems, University of Aizu, Aizu-Wakamatsu City, Fukushima Prefecture 965-8580, Japan. zhuxin@u-aizu.ac.jp
Abstract:
Computer simulation of intracardiac potentials was performed based on a whole-heart model, emphasising applications to Electrophysiology Study (EPS) and catheter ablation. A numerical method was proposed based on a volume conductor model with multiple interfaces and piecewise homogeneity. A model of a normal heart and a model of Wolff-Parkinson-White (WPW) Syndrome with a right free-wall Accessory Pathway (AP) were employed to simulate intracardiac electrograms. The study was validated by comparing the simulated electrograms with those in catheter-based EPS and ablations. Applying whole-heart modelling to the EPS and ablation is regarded as a new direction of electrocardiologic forward problem.

