Denoising Respiratory Sinus Arrhythmia of Pulse-to-Pulse Interval Signals Extracted from Photoplethysmogram with an...

Pulse rate variability (PRV), a critical biomarker of autonomic nervous system (ANS) function, is typically evaluated using the pulse-to-pulse interval (PPI) signal extracted from a photoplethysmogram (PPG). Although PPGs have been widely used in wearable devices, the PPI signal is easily affected by motion artifacts or respiratory sinus arrhythmias (RSAs). These disturbances affect the accuracy of PRV for evaluating ANS function. The aim of this study was to remove the respiratory signals from raw PPI signals with an autoregressive moving average (ARMA) model.

An R-wave to R-wave interval (RRI) sequence was extracted from the electrocardiogram (ECG). A self-made measurement system was used to record PPG, ECG, and respiratory signals. Nineteen healthy adults were recruited and requested to breathe with a spontaneous breathing rate (SBR) and control breathing rates (CBRs) (6, 18, and 30 breathing rate per minute, BRPM). Their ECG, PPG, and breathing signals were recorded for 6 min under different CBRs. The measurement was performed twice, i.e., eight measurements were performed. The raw RRI(t) and PPI(t) signals of 4 Hz were segmented into samples of one minute and shifted by 30 s. Thus, a subject had 80 samples, and there were 10 samples for each BRPM. RSA-free RRI signals were generated by a spectral method to filter RSA from raw RRI(t) to produce the target RRI(t). We proposed the individual subject ARMA models trained by samples with the maximum mean absolute errors between the target RRI(t) and raw PPI(t) (MAE_RAWs) of each subject, and the general model trained by samples with all maximum MAE_RAWs of all 19 subjects.

The mean absolute errors between the target RRI(t) and PPI~(t) predicted by the individual subject ARMA models (MAE_{Subject-Models}) and general ARMA model (MAE_{General-Model}) were used to evaluate the performance of the two models. The results for the MAE_{Subject-Models} and MAE_{General-Model} were 132.5 ± 59.1 ms and 137.8 ± 67.8 ms, respectively, with no significant difference. MAE_{Subject-Models} and MAE_{General-Model} were compared with MAE_RAWs, whose attenuations (ATTs) were 28.5 ± 13.1% and 27.8 ± 12.6%, respectively.

The two proposed models are capable of removing the RSA energy coupled in the raw PPI signals.