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Updated: Feb 8, 2026

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes
Published on: August 13, 2021
Under microscopes the poly(styrene/butadiene) nanoparticles
1Bridgestone Americas Center for Research and Technology, 1200 Firestone Parkway, Akron, OH 44317, USA.
Abstract:
There has been considerable interest, both academic and industrial, in developing synthesis processes for making polymeric nanoparticles. Our effort relied on the nanoassembly concepts of block macromolecules in solutions to prepare particles with a hard core made of crosslinked plastics and a soft shell made of low T(g) elastomer. By a suitable variation of the composition, polymer molecular weight and solute concentration, we were able to produce spherical, ellipsoidal, cylindrical, and chain-like nanoparticles. Under microscopes, the chain-like nanoparticles displayed very rich conformational features in diluted and dense states. Our observation on the conformation characters of the nanochains in 3D diluted state agreed well with the proposition of the self-avoid coil model. However, in 2D dense state, our observation on the nanochains appeared to be in contradiction with the segregated globule model proposed by de Gennes.
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