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Related Experiment Video

Updated: Jul 9, 2026

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

Arterial aging: pathophysiological principles.

Michael F O'Rourke¹

¹St Vincent's Clinic, University of New South Wales, Sydney, Australia. m.orourke@unsw.edu.au

Vascular Medicine (London, England)

|December 1, 2007

Summary

This summary is machine-generated.

Arterial stiffening, not just blood pressure, is key to vascular aging and cardiovascular risk. Monitoring arterial pressure waves offers better insights than traditional cuff measurements for early detection and intervention.

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Isolation and Functional Analysis of Arteriolar Endothelium of Mouse Brain Parenchyma

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Last Updated: Jul 9, 2026

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

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Published on: October 19, 2016

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

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Isolation and Functional Analysis of Arteriolar Endothelium of Mouse Brain Parenchyma

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Published on: March 11, 2022

Area of Science:

Cardiovascular Physiology
Gerontology
Vascular Biology

Background:

Historically, arteriosclerosis was recognized as a marker of vascular aging and cardiovascular risk.
Twentieth-century focus shifted to systolic/diastolic pressure and atherosclerotic disease, overlooking proximal aortic stiffening and dilation.

Observation:

Elastic arteries, primarily the aorta, cushion cardiac output, ensuring steady peripheral flow in youth.
Aortic stiffening with age results from elastin fatigue and collagen stress transfer, impairing its cushioning function.

Findings:

Aortic stiffening increases left ventricular load and myocardial oxygen demand while reducing diastolic blood supply, leading to cardiac failure and ischemia.
Increased aortic stiffness transmits pulsatile flow downstream, damaging microvessels in the brain and kidneys, causing cognitive decline and renal failure.

Implications:

Monitoring arterial pressure waves, rather than cuff sphygmomanometry, can better assess vascular aging.
This approach may enable early detection of arterial degeneration, guiding lifestyle modifications and pharmacological interventions.