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Reproducibility and repeatability of differential renal function in 4-week-old piglets
Thomas H Dissing1, Anni Eskild-Jensen, Michael Pedersen
1Institute of Clinical Medicine, University of Aarhus, Denmark.
Nuclear Medicine Communications
|December 1, 2007
Summary
Differential renal function (DRF) from 99mTc-DMSA scans is reproducible in young pigs, unlike 99mTc-DTPA scans. This finding is crucial for diagnosing congenital obstructive renal disease in infants.
Area of Science:
- Pediatric Nephrology
- Nuclear Medicine
- Medical Imaging
Background:
- Congenital obstructive renal disease necessitates early surgical decisions in children.
- Differential renal function (DRF) from renograms aids these decisions.
- Recent studies question renogram reliability for pediatric DRF.
Purpose of the Study:
- To assess day-to-day variation and reproducibility of two agents for estimating DRF.
- Evaluate 99mTc-DTPA and 99mTc-DMSA for DRF assessment in immature pigs.
Main Methods:
- Four-week-old pigs underwent three examinations with 99mTc-DTPA and 99mTc-DMSA within one week.
- DRF calculated using area under the curve (AUC) and Rutland-Patlak equation for 99mTc-DTPA.
- Analyzed day-to-day variations using coefficient of variation and repeatability coefficient.
Main Results:
- 99mTc-DMSA studies showed low DRF variation (CV 3.9% max).
- 99mTc-DTPA studies exhibited higher variability: AUC (RC 14.9%) and Rutland-Patlak (RC 9.4%).
Conclusions:
- DRF from 99mTc-DMSA studies is highly reproducible in immature pigs.
- DRF from 99mTc-DTPA renograms lacks acceptable reproducibility for pediatric use.
- 99mTc-DMSA is a more reliable agent for DRF assessment in this model.
