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Updated: Jul 9, 2026
05:40
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
Published on: July 29, 2021
[Migraine--mechanisms and consequences for treatment]
Karl Bjørnar Alstadhaug1, Rolf Salvesen
1Nevrologisk avdeling, Nordlandssykehuset, 8092 Bodø. karl.bjornar.alstadhaug@nordlandssykehuset.no
Summary
Migraine attacks may stem from increased brain excitability and cortical spreading depression, potentially involving the brain stem. Serotonin agonists can effectively treat these debilitating headache episodes.
Area of Science:
- Neurology
- Neuroscience
Context:
- Migraine is a prevalent neurological disorder characterized by recurrent headaches.
- Recent advancements have improved our understanding of migraine pathophysiology.
Purpose:
- To synthesize current knowledge on the neurobiological mechanisms underlying migraine attacks.
- To explore the role of cortical spreading depression and brain stem dysfunction in migraine.
Summary:
- Migraine patients exhibit heightened cortical excitability, with attacks potentially initiated by cortical spreading depression.
- This phenomenon can trigger meningeal inflammation and trigeminal nerve irritation.
- Episodic brain stem dysfunction is implicated in migraine generation or contribution, and central sensitization manifests as allodynia.
- Disturbed pain modulation and the efficacy of serotonin agonists highlight neurotransmitter roles.
Impact:
- Provides insights into migraine mechanisms, aiding in the development of targeted therapies.
- Highlights the genetic predisposition contributing to recurrent migraine episodes.
- Enhances understanding of central sensitization and allodynia in migraine patients.
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