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Updated: Jul 9, 2026

09:11
Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
Published on: April 9, 2019
Closed-loop control in fused MR-TRUS image-guided prostate biopsy
Sheng Xu1, Jochen Kruecker, Peter Guion
1Philips Research North America, Briarcliff, NY 10510, USA. sheng.xu@philips.com
Summary
This study introduces a closed-loop control system for targeted prostate biopsy, effectively compensating for prostate motion using real-time imaging and spatial tracking. This enhances biopsy precision and safety.
Area of Science:
- Medical Imaging
- Robotics
- Surgical Navigation
Background:
- Prostate motion during biopsy hinders multi-modality fusion imaging accuracy.
- Targeted prostate biopsy requires precise image registration for efficacy and safety.
Purpose of the Study:
- To develop and evaluate a closed-loop control mechanism for real-time prostate motion compensation during targeted biopsy.
- To improve the accuracy and safety of image-guided prostate interventions.
Main Methods:
- A closed-loop control system utilizing real-time ultrasound and spatial tracking for image registration.
- Preoperative MRI and ultrasound volume registration using 2D sweep data and spatial tracking.
- Real-time feedback adjustment of registration between preoperative 3D and intraoperative ultrasound images.
Main Results:
- Phantom studies demonstrated system accuracy of 2.3 +/- 0.9 mm.
- Twelve patient studies confirmed effective compensation of prostate motion via closed-loop control.
- The proposed system shows potential for enhanced targeted prostate biopsy procedures.
Conclusions:
- Closed-loop control effectively compensates for prostate motion during targeted biopsy.
- The developed system improves the precision and safety of image-guided prostate interventions.
- This approach offers a viable solution for multi-modality fusion imaging challenges in prostate biopsy.

