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Related Concept Videos

Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
Mutations01:35

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
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Other Unique Bacteria

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Related Experiment Video

Updated: Jul 9, 2026

Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation
11:24

Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation

Published on: July 3, 2015

[The phenomenon of the single-strand DNA breaks level decrease in blood system cells in first generation chronically

I O Velegzhaninov, A A Moskalev, A N Osipov

    Radiatsionnaia Biologiia, Radioecologiia
    |December 7, 2007
    PubMed
    Summary
    This summary is machine-generated.

    Chronic low dose-rate gamma radiation exposure in mice offspring reduced DNA breaks and apoptosis. This suggests a more compact chromatin structure in blood cells, impacting radiation response.

    More Related Videos

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    Detection of Inter-chromosomal Stable Aberrations by Multiple Fluorescence In Situ Hybridization (mFISH) and Spectral Karyotyping (SKY) in Irradiated Mice
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    Detection of Inter-chromosomal Stable Aberrations by Multiple Fluorescence In Situ Hybridization (mFISH) and Spectral Karyotyping (SKY) in Irradiated Mice

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    Related Experiment Videos

    Last Updated: Jul 9, 2026

    Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation
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    Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation

    Published on: July 3, 2015

    Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells
    08:18

    Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells

    Published on: September 5, 2017

    Detection of Inter-chromosomal Stable Aberrations by Multiple Fluorescence In Situ Hybridization (mFISH) and Spectral Karyotyping (SKY) in Irradiated Mice
    10:14

    Detection of Inter-chromosomal Stable Aberrations by Multiple Fluorescence In Situ Hybridization (mFISH) and Spectral Karyotyping (SKY) in Irradiated Mice

    Published on: January 11, 2017

    Area of Science:

    • Radiobiology
    • Genetics
    • Cell Biology

    Context:

    • Investigating the long-term effects of chronic low dose-rate gamma radiation exposure.
    • Examining the impact on offspring (F1 generation) of chronically irradiated parents.
    • Focusing on cellular and tissue-level changes in blood and spleen.

    Purpose:

    • To experimentally demonstrate the effects of chronic low dose-rate gamma radiation on DNA integrity, apoptosis, and spleen mass in mice offspring.
    • To propose a hypothesis regarding chromatin structure alterations in response to parental irradiation.

    Summary:

    • Chronic low dose-rate gamma radiation (0.04 mGy/hr) exposure significantly decreased single-strand DNA breaks in spleen cells (2.3x) and blood leukocytes (6.1x).
    • Apoptotic cell frequency decreased by 1.3x, while relative spleen mass increased by 1.2x in offspring exposed during development.
    • These findings support a hypothesis of a more compact chromatin structure in blood cells of the first generation from chronically irradiated mice.

    Impact:

    • Provides novel experimental evidence on the adaptive responses to chronic low-dose radiation at the cellular level.
    • Suggests potential epigenetic modifications, specifically chromatin structure changes, in response to radiation.
    • Highlights the importance of studying transgenerational effects of radiation exposure on biological systems.