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The Level of Ischemia-Modified Albumin in Healthy Individuals of Different Age Groups
Yu O Teselkin1, I V Babenkova2, I V Tarasova2
1Pirogov Russian National Research Medical University (Pirogov University), Ministry of Health of the Russian Federation, Moscow, Russia. teselkin-box@mail.ru.
Abstract:
The serum levels of oxidative stress marker, ischemia-modified albumin (IMA) were studied in healthy young (18-49 years), middle-aged (51-68 years), elderly and older (73-99 years) people. The content of IMA was measured using albumin cobalt binding assay. In addition, the IMA/albumin ratio (IMAR) was calculated. The content of IMA was elevated in the elderly individuals in comparison with the other two age groups (p < 0.05). Similar changes were observed for IMAR (p < 0.01). A positive correlation was established between the levels of IMA, IMAR, and age in the total group of volunteers (r = 0.308, p < 0.05 and r = 0.412, p < 0.01, respectively). The results show that oxidative modification of serum albumin increases with age.
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