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Updated: Jul 9, 2026
An Intact Pericardium Ischemic Rodent Model
Published on: September 2, 2021
[Hemocompatibility of bovine pericardium with additional sodium bisulfite treatment]
Mao-sheng Han1, Jian-ye Zhou, Sheng-shou Hu
1Research Center for Cardiovascular Regeneration Medicine of the Ministry of Health, Cardiovascular Institute and Fuwai Hospital, CAMS and PUMC, Beijing 100037, China.
Objective:
To evaluate the hemocompatibility of glutaraldehyde (GA)-tanned bovine pericardium additionally treated by sodium bisulfite (SOB) solution.
Methods:
The hemocompatibility of GA-tanned bovine pericardium treated by SOB solution is evaluated by using dynamic clotting time test, blood platelet adhension test, D-dimeride determination, and complement activation test. The GA-tanned bovine pericardium was used as control.
Results:
The curve of absorbance-clotting time of two kinds of bovine pericardium was similar in dynamic clotting time test. There was no significant difference between SOB-treated and control groups in blood platelet adhension test. The D-dimeride contents of all bioprostheses were at normal level, and the D-dimeride content of GA-tanned bovine pericardium treated by SOB solution was significantly lower than that of control group (P < 0.05). In complement activation test, the level of complement C3a in SOB-treated group was significantly lower than that in control group (P < 0.05).
Conclusion:
GA-tanned bovine pericardium treated by SOB solution meets the demands of cardiac interstitial implanted materials in hemocompatibility.
