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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
[Carcinosarcoma of the prostate: a case report]
Takahiro Yoshida1, Takeshi Ujike, Motohide Uemura
1Department of Urology, Osaka Rosai Hospital.
Hinyokika Kiyo. Acta Urologica Japonica
|December 7, 2007
Summary
Prostate carcinosarcoma is a rare and aggressive cancer. This case highlights its poor prognosis and rapid progression, even after extensive surgery.
Area of Science:
- Oncology
- Pathology
Background:
- Carcinosarcoma of the prostate is an exceptionally rare and aggressive malignancy.
- Optimal treatment strategies and prognosis remain poorly defined due to limited case reports.
Observation:
- A 63-year-old male presented with dyschezia and dysuria, later diagnosed with a large prostate mass.
- Initial biopsy suggested fibrosarcoma, but histopathology confirmed carcinosarcoma.
- The patient underwent total pelvic exenteration, but experienced rapid local recurrence and succumbed to the disease within nine months.
Findings:
- Prostate carcinosarcoma is characterized by aggressive local recurrence and rapid progression.
- Despite surgical intervention, the prognosis for this rare tumor is generally poor.
Implications:
- This case underscores the aggressive nature of prostate carcinosarcoma and the urgent need for research into effective treatment protocols.
- Further investigation is crucial to improve outcomes for patients diagnosed with this rare neoplasm.
