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[Cutaneous permeation comparison of Kechuan acupoint patch and power]
Qun He1, Gui-Ming Deng, Guang-Nin Yang
1College of Pharmaceutics, HuNan University of Traditional Chinese Medicine and Drug, Changsha 410208, China. hequn88@126.com
Objective:
To compare the cutaneous permeation of Kechuan acupoint patch and power, and evaluate the possibility of dosage form reform of Kechuan recipe.
Method:
Take the Eugend and Ephedrine as the indexes, HPLC was employed to determine their contents, the pond with Franz diffusion were used to measured the cutaneous.
Result:
The permeation of Patch matched with Higuchi Equation. Take Eugend as the index, the permeation rate of total of Patch is 2.319 and 1.738 times of the powder, and 1.784 and 1.215 times of the powder with the Ephedrineas as index.
Conclusion:
The permeation rate of Kechuan acupoint patch was more rapid than the powder. Moreover, the total quantity of permeation of patch was also more than the powder.