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Updated: Jul 9, 2026

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
Published on: October 15, 2019
Preparation of novel beta-cyclodextrin chiral stationary phase based on click chemistry
Yongping Zhang1, Zhimou Guo, Jinxing Ye
1School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Abstract:
A facile strategy based on click chemistry for preparation of the structurally well-defined native beta-cyclodextrin (beta-CD) based chiral stationary phase (CSP) was proposed. The beta-CD CSP was evaluated by enatioseparation of benzoin, trans-stilbene oxide, Troger's base, bendroflumethiazide, ketoprofen, chlorthalidone, three flavanone compounds and two beta-adrenergic blocking agents under reversed phase high performance liquid chromatography. The chromatographic results demonstrate the chiral separation ability of click beta-CD CSP and illustrate the usefulness of click chemistry in the preparation of beta-CD based CSP.
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