Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lateral Retention Force and Directional Energy Barrier of a Droplet on a Microgrooved Hydrophobic Surface.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Direct electrochemical oxidation of alkylarenes to aryl aldehydes and ketones.

Chemical communications (Cambridge, England)·2026
Same author

Bridging Microscopic Interfacial Water and Macroscopic Wettability for Enhanced Hydrogen Evolution Reaction.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

DNA Nanotechnology-Enabled Precise Regulation of Nanozymes and Their Applications.

Research (Washington, D.C.)·2026
Same author

Low-Temperature Ethanol Gas Sensor Based on MoO<sub>3</sub>/Nb<sub>2</sub>C MXene Composite via Crystal Engineering and Facet Release.

Sensors (Basel, Switzerland)·2026
Same author

Case Report: Beyond the ulcer: 51-month durability of left gastric artery embolization for obesity management in an antiplatelet-dependent, surgery-ineligible patient.

Frontiers in nutrition·2026

Related Experiment Video

Updated: May 24, 2026

A Modular Microfluidic Technology for Systematic Studies of Colloidal Semiconductor Nanocrystals
09:58

A Modular Microfluidic Technology for Systematic Studies of Colloidal Semiconductor Nanocrystals

Published on: May 10, 2018

Continuous flow modular synthetic platform for accelerated drug discovery.

Maolin Sun1, Rixin Shao1, Haoxiang Chen1

  • 1School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, China.

European Journal of Medicinal Chemistry
|May 22, 2026
PubMed
Summary

A new automated flow synthesis platform accelerates drug discovery by enabling rapid, high-throughput production of diverse compound libraries. This technology identified potent new antibiotics effective against drug-resistant bacteria.

Keywords:
Antibacterial lead compoundsAutomated synthesis platformContinuous flow synthesisDrug discoveryHigh-throughput synthesisModular synthesisQuinolone library

More Related Videos

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
11:23

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

Related Experiment Videos

Last Updated: May 24, 2026

A Modular Microfluidic Technology for Systematic Studies of Colloidal Semiconductor Nanocrystals
09:58

A Modular Microfluidic Technology for Systematic Studies of Colloidal Semiconductor Nanocrystals

Published on: May 10, 2018

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
11:23

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

Area of Science:

  • Medicinal Chemistry
  • Drug Discovery
  • Chemical Biology

Background:

  • Drug discovery faces challenges in efficiently synthesizing diverse compound libraries.
  • Automated synthesis platforms are crucial for accelerating the identification of novel therapeutic agents.

Purpose of the Study:

  • To develop and validate a fully automated modular flow synthesis platform for rapid, high-throughput compound library generation.
  • To demonstrate the platform's capability in discovering novel antibiotic candidates against multidrug-resistant bacteria.

Main Methods:

  • Integration of continuous flow chemistry and automation technologies for modular synthesis.
  • Systematic structural diversification to construct quinolone-based libraries.
  • Biological screening of synthesized compounds for antibacterial activity.

Main Results:

  • The platform achieved a 60-fold acceleration in quinolone synthesis compared to batch methods.
  • A 409-member quinolone library was synthesized, yielding potent antibacterial candidates (S)-C-9-21 and C-1-13.
  • Candidate (S)-C-9-21 demonstrated significant efficacy in a murine thigh infection model, reducing bacterial load by 100-fold.

Conclusions:

  • The developed automated flow synthesis platform is a scalable and versatile tool for accelerating drug discovery.
  • The platform facilitates rapid exploration of chemical space and identification of promising drug candidates, including novel antibiotics.
  • This approach bridges synthetic chemistry and biological screening, offering a blueprint for next-generation drug development.