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Published on: February 13, 2016
A novel system for three-pulse drug release based on "tablets in capsule" device
Bin Li1, JiaBi Zhu, Chunli Zheng
1Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, NanJing, Jiangsu 210038, PR China.
International Journal of Pharmaceutics
|December 7, 2007
Summary
This study developed a novel capsule system for programmed drug delivery, enabling pulsatile release three times daily. Formulation adjustments successfully controlled drug release timing for improved therapeutic outcomes.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Pulsatile drug delivery aims to mimic physiological patterns, improving therapeutic efficacy.
- Novel oral drug delivery systems are needed to achieve controlled, multi-release profiles.
Purpose of the Study:
- To develop and evaluate a novel capsule system for programmed, pulsatile drug release.
- To control lag times between multiple drug release pulses through formulation design.
Main Methods:
- Formulation of a capsule system with a water-soluble cap and multi-layered tablets.
- Utilizing sodium alginate and hydroxypropyl methylcellulose (HPMC E5) as modulating barrier materials.
- Investigating the effect of material ratios and bulking agents (lactose, NaCl) on drug release profiles.
Main Results:
- Lag time between the first two pulses was controllable by adjusting the sodium alginate/lactose ratio.
- Lag time between the second and third pulses was modulated by the HPMC E5/lactose ratio.
- Lactose was identified as a favorable bulking agent for drug release rate.
Conclusions:
- Programmed pulsatile drug delivery, three times daily, is achievable with this novel capsule system.
- Systemic formulation approaches allow for precise control over drug release timing.
- The developed system offers a promising strategy for optimizing oral drug delivery.
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