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[Angiogenesis inhibitor therapies: focus on hypertension and kidney toxicity]

Hassan Izzedine1

  • 1Service de Néphrologie, Hôpital Pitié-Salpêtrière, 83, Boulevard de l'Hôpital, 75013 Paris, France. hassan.izzedine@psl.aphp.fr

Bulletin Du Cancer
|December 7, 2007
PubMed

Insights

Molecular biology advances reveal angiogenesis is crucial in cancer. This article details anti-angiogenic therapies for metastatic renal cell carcinoma (RCC) and their potential kidney side effects.

Area of Science:

  • Cancer molecular biology
  • Tumor angiogenesis
  • Renal cell carcinoma (RCC) pathophysiology

Context:

  • Over 20 years of molecular biology research in cancer.
  • Angiogenesis is a critical factor in cancer progression.
  • Emerging anti-angiogenic therapies for metastatic RCC.

Purpose:

  • To review the role of angiogenesis in cancer.
  • To discuss anti-angiogenic strategies targeting VEGF and PDGF pathways.
  • To present the renal toxicity associated with these therapies.

Summary:

  • Anti-angiogenic drugs targeting VEGF receptors or protein, and other kinases like PDGF, are used for metastatic RCC.
  • These targeted therapies, while effective, can have significant interactions with the kidneys.
  • The article outlines the clinical and pathological aspects of renal toxicity.

Impact:

  • Provides insights into the mechanisms of anti-angiogenic drug-induced kidney damage.
  • Informs clinicians about potential renal side effects in RCC patients.
  • Contributes to the understanding of targeted cancer therapy complications.

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