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Updated: Mar 24, 2026
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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
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Cancer therapy and the kidney
Hassan Izzedine1, Mark A Perazella2, Krishna Mohita Kuruvada3
1Department of Nephrology, Peupliers Private Hospital, Paris, France.
Kidney International
|March 22, 2026
Summary
Cancer treatments improve outcomes but can harm kidneys, causing acute kidney injury (AKI) and chronic kidney disease (CKD). Onconephrology collaboration is key to managing these renal toxicities.
Area of Science:
- Oncology
- Nephrology
- Pharmacology
Background:
- Cancer therapies have advanced, improving patient survival rates.
- Concurrent increases in therapy-related kidney complications (nephrotoxicity) are observed.
- Nephrotoxicity encompasses acute kidney injury (AKI), chronic kidney disease (CKD), and electrolyte imbalances.
Purpose of the Study:
- To review kidney complications associated with modern anti-cancer therapies.
- To explain the mechanisms of cancer therapy-induced kidney damage.
- To discuss risk evaluation and mitigation strategies in onconephrology.
Main Methods:
- Comprehensive literature review of anti-cancer therapies and associated nephrotoxicity.
- Analysis of pathophysiological mechanisms underlying renal complications.
- Synthesis of current guidelines for kidney function assessment and risk management.
Main Results:
- Various anti-cancer agents (chemotherapy, targeted therapy, immunotherapy) can cause significant renal toxicity.
- Renal toxicities can necessitate cancer treatment modification, impacting efficacy.
- Emerging therapies present new challenges in onconephrology.
Conclusions:
- Multidisciplinary collaboration between oncologists and nephrologists is crucial.
- Optimizing renal outcomes is essential for maintaining cancer treatment and improving patient quality of life.
- Advances in onconephrology are vital for managing patients receiving cancer therapies.
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